NSX will, by default, only discover VMs with IPv4. This is due to the default configuration for IP Discovery, as you can see in the image above. If you have IPv6 VMs, you should consider creating a new segment profile that also includes IPv6: NSX Manager > Networking > Segments > Profiles > Add Segment… Read More When using IPv6 in NSX-T segments – remember to create an IP discovery profile which includes IPv6 address snooping methods